In present study, immediate release tablets were prepared using nanocrystals to optimize dissolution properties of lipophilic, poorly soluble drug nateglinide (NTG). Different batches of nanocrystals were prepared by 32 full factorial design using DOE software. The factorial design used for optimization of preparation to independent factor concentration ratio of poloxamer 188 and stirring speed also with dependant factor particle size and dissolution rate. The nanocrystal preparation was prepared by high pressure homogenization techniques and poloxamer 188 as stabilizer. Characterization of NTG nanocrystals was carried out by infrared spectroscopy (FTIR), x-ray powder diffractometry (XRPD), differential scanning calorimetry and photon correlation spectroscopy. Dissolution study of NTG nanocrystals immediate release tablet was performed in 0.1 N HCl and was compared to that of NTG coarse suspension, NTG/poloxamer 188 physical mixture and bulk NTG samples. The solubility of the NTG nanocrystals immediate release tablet formulation conclude that the improvement in NTG dissolution rate was mainly caused by increased surface to volume ratio due to the submicron dimension of the drug particles.
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